ACT statistics - a dashboard
For the data fiends, the local government has built this dashboard: Microsoft Power BI
It has four parts.
Its not bad.
My area is "Molonglo" (Its a lovely area. visit some time :) )
Data sources are listed on page 4.
In more OUTSTANDINGLY BAD news....
This ...thing... keeps getting worse.
Apologies to be so spammy tonight (SWMBO is sick and in bed, so Im a tad bored!).
https://www.biorxiv.org/content/bior...06213.full.pdf
and a preview of the info:
Quote:
"In this study, we selected 95 strains of SARS-CoV-2, isolated from 11 different countries...The results obtained...indicate high severity of SARS- CoV-2 ...with inherent capability of unique mutations and the evolving viral replication strategies to adapt to human hosts."
Development of universal vaccines against the novel SARS-CoV-2 holds utmost urgency...However...the underlying severity hidden in the SARS-CoV2 genomes is required to be fully understood.
We revealed unique single nucleotide polymorphisms (SNPs)...within 10 viral isolates from USA. These ...[indicate] highly evolved strains of the novel SARS-CoV-2 circulating in the population of USA [more] than in other countries.
Furthermore, we found an isolate from USA...to carry frameshift mutation... Thus, we reason that the replicative machinery of the novel SARS-CoV-2 is fast evolving to evade host challenges and survival.
These mutations are needed to be considered, otherwise it will be difficult to develop effective treatment strategies.
...two proteins also...might confer selective advantage to the virus. Through the construction of SARS-CoV-2-human interactome, we further reveal multiple host proteins...which are manipulated...for mediating host immune mechanism for its survival.
In this study, we selected 95 strains of SARS-CoV-2, isolated from 11 different countries to understand the transmission patterns, evolution and pathogenesis of the virus.
The results obtained from the analyses indicate high severity of SARS- CoV-2 isolates with inherent capability of unique mutations and the evolving viral replication strategies to adapt to human hosts.
...two genes...found to...enhance the multiplication and facilitate growth of [the] virus inside the host.
Similarly, the S protein which helps in the entry of virus to the host cells...[was] found to be accelerated towards...the successful ability of enzyme to initiate the infection.
Another positive diversifying gene...protects the genetic material of virus from host immune responses...
Overall, the data represent that the growth and multiplication related genes are highly evolving.
Although the primary mode of infection is human to human transmission through close contact, which occurs via spraying of nasal droplets from the infected person, the primary site of infection and pathogenesis of SAR-CoV-2 is still not clear and under investigation.
The genomes of six isolates, specifically from USA, were found to harbour unique amino acid SNPs and showed amino acid substitutions in ORF1b protein and S-protein, while one of them also harboured a frameshift mutation. This is suggestive of the severity of the mutating viral genomes within the population of USA. These proteins are directly involved in formation of viral replication-transcription complexes (RTC).
Therefore, we argue that the novel SARS- CoV-2 has fast evolving replicative machinery and that it is urgent to consider these mutants in order to develop strategies for COVID19 treatment...these mutants...might confer selective advantage to evade host responsive mechanisms...It is predicted that major immune-pathogenicity mechanism by SARS-CoV-2 includes the host cell environment alteration by disintegration by signal transduction pathways and immunity evasion by several protection mechanisms. The mode of entry of this virus by S-proteins inside host cell is still unclear but it might be similar to SARS CoV-1 like viruses.
Lastly, we believe that COVID-19 is being transmitted from human to human, but as more data accumulate the picture will be more clear, as these virus spread beyond the imagination of scientific community.
